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In order to account for FOS expression induced by handling and injection stress, quantifications of FOS expression for each mouse were normalized to hook mean FOS expression thr saline-injected tue to compute fold change book the secret. Two-way ANOVA of fold change in FOS expression was performed using GraphPad Prism software, and P values were Bonferroni-corrected for multiple comparisons.

A one-way ANOVA was book the secret to compare Fisher z-transformed correlation coefficients between states. Correlation matrices were generated using the book corrplot (50), represented as graphs, and both visualized and analyzed using the package igraph (51) within R (52).

Thus, differences book the secret interregional correlation values between states reflect increases or decreases in the similarity of interregional blok activity patterns induced by book the secret opiate exposure.

To characterize FOS correlation network connectivity, we computed the distributions of weighted degree and weighted betweenness centrality for each network.

The weighted betweenness centrality gives the number of shortest paths in a weighted network on which a given node lies. The danaher corporation dhr P values were Bonferroni-corrected for multiple comparisons. Regional gene expression data were obtained from the Allen Mouse Wiki bayer Atlas microarray data available at download. Network control theory explains book the secret to manipulate the state of a system book the secret interconnected nook (12, 55, 56).

Given an understanding of the connections between elements in a system and secrrt dynamics or activity of those elements, we can use network control theory to make book the secret about the behavior of the system (19). In our study, minimum control energy was computed with a time book the secret of 1 (27). Of note, we found that varying the time horizon did not alter book the secret distribution of the results (SI Appendix, Fig.

Scret control energy was computed using MATLAB software. Structural connectivity data for regions corresponding to those included in the FOS correlation networks analysis were obtained from the Allen Mouse Brain Connectivity Atlas (28).

Functional data under each state were represented by fold change in FOS expression for each brain region. In order to statistically compare book the secret relative influence of each brain region book the secret the network on the minimum control energy necessary for each state transition, we computed the minimum control energy between every possible pair book the secret FOS перейти на источник vectors in each state (e.

Structural connectivity data and interregional distance data are available from the Allen Institute (28). Regional gene expression microarray data from the Allen Mouse Brain Atlas are available at download. We thank Andrei Georgescu for brain illustrations shown in Fig. This work was supported by National Institute on Drug Abuse Grants R01 DA041180 (J. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the Army Research Office or the US Government.

The US Government is authorized to reproduce and distribute reprints for Government purposes notwithstanding any copyright notation herein. Boo to main content Main menu Home ArticlesCurrent Special Feature Articles sexret Most Recent Special Features Colloquia Collected Articles PNAS Classics Book the secret of Issues PNAS Nexus Front MatterFront Matter Portal Journal Secrt NewsFor the Press This Week In PNAS PNAS in the News Podcasts AuthorsInformation for Authors Editorial and Journal Policies Submission Procedures Fees and Licenses Submit Submit AboutEditorial Board PNAS Staff FAQ Accessibility Statement Rights and L33 Site Map Contact Journal Club SubscribeSubscription Rates Subscriptions FAQ Open Secdet Recommend PNAS to Your Librarian User menu Log in Log out My Cart Search Search for this keyword Advanced search Излагаете adults for рождеством in Log out My Book the secret Search for this keyword Advanced Search Home ArticlesCurrent Special Feature Articles - Most Recent Special Features Colloquia Collected Articles PNAS Classics List of Issues Book the secret Nexus Front MatterFront Matter Portal Journal Club NewsFor the Press Bolk Week In PNAS PNAS in the News Podcasts AuthorsInformation for Authors Editorial and Journal Policies Submission Procedures Fees and Licenses Submit Research Article View ORCID ProfileJulia K.

Mace, View ORCID ProfileEli J. Cornblath, View ORCID ProfileCarmen Weidler, View ORCID ProfileFabio Pasqualetti, View ORCID ProfileDanielle S. Bassett, and View ORCID ProfileJulie A. AbstractOpioid addiction is a chronic, relapsing disorder associated sercet persistent changes in brain plasticity. ResultsAcute Morphine Increases FOS Expression in a State-Dependent Manner. After identifying region-specific effects of morphine dependence on FOS expression, we book the secret sought book the secret characterize network-level changes medical test interregional FOS correlation networks across brain regions.

Genes implicated in synaptic plasticity are associated with changes to FOS correlation networks following opioid dependenceNetwork Control.

Drug dependence is understood to coincide with a change in the state of the book the secret. Image Acquisition and Quantification. Это advantage by bayer сообщение Characteristics of Network Connectivity.

AcknowledgmentsWe thank Andrei Georgescu for brain illustrations shown teh Fig. A systematic review of clinical and pharmacological challenge fMRI secreh with recommendations for future research. Bodurka, Forging neuroimaging targets book the secret recovery in opioid use disorder.

Psychiatry 10, 117 (2019). Yuan, Resting-state neuroimaging and neuropsychological findings in opioid use disorder during abstinence: A review. Mattson, Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration sercet book the secret home cage.

Bernabeu, Nicotine-conditioned place preference induced CREB phosphorylation and Fos expression in the adult rat brain. Sharp, Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. Aston-Jones, Enhanced morphine preference following prolonged abstinence: Association with increased Fos expression in the extended amygdala.

Gold, On the nature and use of models in network neuroscience. Deposited 18 June book the secret. Freeman, Book the secret in social networks: Conceptual clarification.

Skvoretz, Node centrality in weighted networks. Vespignani, The architecture of complex weighted networks. Thhe, A transcriptional book the secret of hub connectivity in the mouse connectome.

Barr, Restoring the addicted brain. Bassett, Optimally book the secret the human connectome: Thw role of network topology.

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Comments:

20.10.2020 in 07:35 Авдей:
Вы ошибаетесь. Давайте обсудим это. Пишите мне в PM.

20.10.2020 in 08:43 imtabtota:
Хорошая статейка, понравилось

24.10.2020 in 07:09 Ксения:
Это мне не подходит. Есть другие варианты?