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Patients were randomly assigned either to switch to aripiprazole or to stay Neupogen (Filgrastim Injection)- Multum olanzapine, on a 1:1 basis. Esrd over a period of 1 month was done while switching patients to aripiprazole.

Results: All parameters of metabolic syndrome (waist circumference, blood pressure, triglyceride level, fasting blood glucose, and high-density lipoprotein cholesterol) kept deteriorating in the stay group, Neupogen (Filgrastim Injection)- Multum with a continuous improvement in the switch group over time.

Keywords: metabolic syndrome, olanzapine, aripiprazole, schizophrenia, switchingCorrigendum has been published for this paperMetabolic syndrome a complex disorder comprising a set of cardiovascular risk factors, including obesity, dyslipidemia, deranged glucose metabolism, insulin insensitivity, and hypertension.

Studies show that metabolic syndrome is associated with twofold to threefold increased risk of cardiovascular morbidity. These metabolic abnormalities are further aggravated by antipsychotic medications. Aripiprazole has a unique mechanism of action among second-generation antipsychotic medications: it is a partial agonist at D2 dopamine and 5-HT1A serotonin receptors and an antagonist at 5-HT2A serotonin receptors. We hypothesized that switching to aripiprazole would result in an improvement ссылка на продолжение metabolic measures, compared with staying on olanzapine.

We were also interested in determining if switching to aripiprazole would be accompanied by any clinical destabilization. Earlier, Fleischhacker et al30 in their study comparing the efficacy and tolerability of aripiprazole with olanzapine in patients with schizophrenia found that olanzapine had a statistically significant efficacy advantage over aripiprazole, with more reduction in Positive and Negative Syndrome Scale (PANSS) total score.

Pae et al31 found that Neupogen (Filgrastim Injection)- Multum switched to aripiprazole, with sudden discontinuation of the previous antipsychotic medication, showed an increase in symptom severity during first week of switching. Moreover, few studies have been done in this field,32,33 and none has been our Kashmir region.

The study was carried out at the outpatient unit of a tertiary care psychiatry hospital in North India (Kashmir) from June 2011 to May 2014, after seeking permission Neupogen (Filgrastim Injection)- Multum the IEC of the government medical college, Srinagar. Participants were individuals with schizophrenia who had achieved clinical stability with olanzapine and who were assessed as having metabolic syndrome using modified National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP-III) criteria.

The patients entered the study in order to improve their metabolic Neupogen (Filgrastim Injection)- Multum profile. Neupogen (Filgrastim Injection)- Multum consent was obtained from each patient after Neupogen (Filgrastim Injection)- Multum explaining the study procedures.

Individuals assigned to stay on olanzapine больше информации on their prestudy dosage, with adjustments only as clinically indicated. PANSS was used at baseline and 24 weeks, while the Clinical Global Impressions severity subscale (CGI-S) was used pfizer shares baseline and the Clinical Neupogen (Filgrastim Injection)- Multum Impressions improvement subscale (CGI-I) was used at 24 weeks.

The addition of lithium, valproate, statins, or drugs prescribed for weight loss was not allowed during основываясь на этих данных study. Those who were taking these medications during the prestudy phase were allowed to continue without dose adjustments.

All other medications except for nonstudy antipsychotic drugs were allowed. The waist circumference was measured in a horizontal plane, midway between the inferior margin of the ribs and the superior border of the iliac crest. The measurements were taken thrice and the mean was computed in all cases. Systolic and diastolic blood pressure were measured twice at an interval of 3 minutes in the sitting position after 15-minute rest, and the mean was computed.

Metabolic syndrome was diagnosed using modified NCEP ATP-III criteria for читать больше Asian population.

Assessment for Neupogen (Filgrastim Injection)- Multum clinical destabilization was done using the PANSS and CGI scales. Continuous variables were summarized as mean and standard deviation. Categorical variables were summarized as percentages.

CGI-I and CGI-S were summarized as median and interquartile range. Neupogen (Filgrastim Injection)- Multum analysis of variance was used to analyze the difference in the values of a continuous variable over time. The proportion of metabolic syndrome across time was tested using the Cochran Neupogen (Filgrastim Injection)- Multum. The progression of the two groups through the study is shown in Figure 1.

Table 1 summarizes the sociodemographic characteristics of the participants. Table 2 shows both intergroup and within-group trends in various metabolic and clinical variables. Last observation carried forward was employed for data imputation. Among the various parameters of metabolic syndrome, waist circumference, blood pressure, triglyceride level, and fasting blood glucose kept increasing in the stay group, while HDL level showed a decreasing trend.

In the switch group, waist circumference, blood pressure, triglyceride level, and fasting blood glucose kept decreasing, while HDL level increased Neupogen (Filgrastim Injection)- Multum time.

Table 3 shows the analysis of completers versus noncompleters of the study.



13.07.2020 in 03:13 Панфил:
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16.07.2020 in 15:45 Флорентина:
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17.07.2020 in 04:25 Аггей:
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18.07.2020 in 08:44 Аверкий:
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